The drug mafia has increased in India, where more and more youngsters are addicted to drugs and taking their lives. The Mumbai police decides to get suspended officer Radhe (Salman Khan) on duty to clean the city. Radhe joins soon and firstly makes two rival groups of Dagdu Dada and Dilwar to join hands as they are against the drug business and will help him clean the city. Radhe's reporting officer is funny, ACP Avinash Abhyankar, who runs away with Radhe's credits while Radhe loves Avinash's sister Dia and pretends to be an upcoming model. Rana the drug lord who has landed in Mumbai and forces people to sell drugs and gets Dilwar killed from his brother Mansoor who works for him, Radhe manages to trace Rana which starts a long cat and mouse race between them.